When I am in pristine mountainous settings I rarely purify my water. In these environments I am very close to the watershed divides, and most of the water that I am drinking is coming from springs or very small creeks (which start as springs not too far uphill) so the risk of a contamination source being in the water is low. I am selective about my water sources: I look for clean creeks and streams, ideally that are full of spongy green moss and far away from any industrialized or agricultural area. If I don't like the water source, I move on. I have hiked thousands of miles without purifying my water and have never gotten sick.
When I'm not in pristine mountainous settings -- and, instead, in areas that are low-lying, beaver-infested, cow-populated, human-inhabited, etc. -- I more frequently purify my water using a chlorine-based purification treatment like Aqua Mira.
Compared to iodine, Aqua Mira is:
Compared to water filters, Aqua Mira is: